Tropical Splenomegaly Syndrome in Zambia: Further Observations and Effects of Cycloguanil and Proguanil
Identifieur interne : 003B61 ( Main/Exploration ); précédent : 003B60; suivant : 003B62Tropical Splenomegaly Syndrome in Zambia: Further Observations and Effects of Cycloguanil and Proguanil
Auteurs : M. N. Lowenthal ; E. C. O'Riordan ; M. S. R. HuttSource :
- British Medical Journal [ 0007-1447 ] ; 1971-02-20.
English descriptors
- Teeft :
- Antimalarial, Antimalarial therapy, Biopsy, British medical_journal, Care unit, College hospital, Cycloguanil, Cycloguanil pamoate, East african, Final exam, Good response, Hepatic, High incidence, Hutt, Initial response, Laboratory findings, Large doses, Liver biopsy, Lowenthal, Lymphocytosis, Lymphomatous transformation, Myocardial infarction, Oral anticoagulants, Other drugs, Overt haemolytic anaemia, Pamoate, Pfizer research fellow, Present study, Previous experience, Proguanil, Pulmonary embolism, Royal society, Sagoe, Significant reduction, Similar results, Spleen, Spleen size, Splenomegaly, Staff members, Syndrome, Thrombosis, Total dose, Tropical medicine, Tropical splenomegaly syndrome, World health organization, Zambia, Zambian patients.
Abstract
Nineteen Zambian patients with the tropical splenomegaly syndrome and sinusoidal lymphocytosis on liver biopsy were studied. The association of macrobulinaemia with the tropical splenomegaly syndrome has again been confirmed. Sixteen patients were treated with antimalarials—12 with cycloguanil pamoate alone, 3 with cycloguanil and proguanil, and 1 with proguanil alone. Twelve patients were observed for periods of sufficient length for the drug effect to be assessed, and in 11 there was a good response in terms of decrease in spleen size. Cycloguanil pamoate may be of value both for prophylaxis and treatment in areas where tropical splenomegaly syndrome is endemic.
Url:
DOI: 10.1136/bmj.1.5746.429
Affiliations:
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Hutt</name></author></analytic><monogr></monogr><series><title level="j">British Medical Journal</title><title level="j" type="abbrev">Br Med J</title><idno type="ISSN">0007-1447</idno><idno type="eISSN">1468-5833</idno><imprint><publisher>British Medical Journal Publishing Group</publisher><date type="published" when="1971-02-20">1971-02-20</date><biblScope unit="volume">1</biblScope><biblScope unit="issue">5746</biblScope><biblScope unit="page" from="429">429</biblScope></imprint><idno type="ISSN">0007-1447</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-1447</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antimalarial</term><term>Antimalarial therapy</term><term>Biopsy</term><term>British medical_journal</term><term>Care unit</term><term>College hospital</term><term>Cycloguanil</term><term>Cycloguanil pamoate</term><term>East african</term><term>Final exam</term><term>Good response</term><term>Hepatic</term><term>High incidence</term><term>Hutt</term><term>Initial response</term><term>Laboratory findings</term><term>Large doses</term><term>Liver biopsy</term><term>Lowenthal</term><term>Lymphocytosis</term><term>Lymphomatous transformation</term><term>Myocardial infarction</term><term>Oral anticoagulants</term><term>Other drugs</term><term>Overt haemolytic anaemia</term><term>Pamoate</term><term>Pfizer research fellow</term><term>Present study</term><term>Previous experience</term><term>Proguanil</term><term>Pulmonary embolism</term><term>Royal society</term><term>Sagoe</term><term>Significant reduction</term><term>Similar results</term><term>Spleen</term><term>Spleen size</term><term>Splenomegaly</term><term>Staff members</term><term>Syndrome</term><term>Thrombosis</term><term>Total dose</term><term>Tropical medicine</term><term>Tropical splenomegaly syndrome</term><term>World health organization</term><term>Zambia</term><term>Zambian patients</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nineteen Zambian patients with the tropical splenomegaly syndrome and sinusoidal lymphocytosis on liver biopsy were studied. The association of macrobulinaemia with the tropical splenomegaly syndrome has again been confirmed. Sixteen patients were treated with antimalarials—12 with cycloguanil pamoate alone, 3 with cycloguanil and proguanil, and 1 with proguanil alone. Twelve patients were observed for periods of sufficient length for the drug effect to be assessed, and in 11 there was a good response in terms of decrease in spleen size. Cycloguanil pamoate may be of value both for prophylaxis and treatment in areas where tropical splenomegaly syndrome is endemic.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hutt, M S R" sort="Hutt, M S R" uniqKey="Hutt M" first="M. S. R." last="Hutt">M. S. R. Hutt</name><name sortKey="Lowenthal, M N" sort="Lowenthal, M N" uniqKey="Lowenthal M" first="M. N." last="Lowenthal">M. N. Lowenthal</name><name sortKey="O Riordan, E C" sort="O Riordan, E C" uniqKey="O Riordan E" first="E. C." last="O'Riordan">E. C. O'Riordan</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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